Ilomastat (GM6001) is a potent and broad spectrum matrix metalloprotease ( MMP ) inhibitor, inhibits MMPs ( IC 50 s, 1.5 nM for MMP-1 ; 1.1 nM for MMP-2 ; 1.9 nM for MMP-3 ; 0.5 nM for MMP-9 ), with a K i of 0.4 nM for human skin fibroblast collagenase ( MMP-1 ).
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