AurkA allosteric-IN-1

Overview

AurkA allosteric-IN-1 (compound 6h) is an Aurora A ( AurkA ) inhibitor ( IC 50 : 6.50 μM) that inhibits the catalytic activity and non-catalytic functions of Aurora A . Aurora A regulates the assembly of the bipolar mitotic spindle and the fidelity of chromosome segregation during mitosis and has non-catalytic functions. AurkA allosteric-IN-1 blocks the interaction of AurkA with the activator TPX2 by binding to the Y pocket of AurkA.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Lung Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Aurora Kinase | Products > Signaling Pathways > Mitosis

Product Information

• Catalog No.: HY-158038
• CAS No.: 3035323-39-5
• Molecular Formula: C20H16N2O3
• Molecular Weight: 332.35
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source