FGFR4-IN-19 (compound 8B) is a potent covalent fibroblast growth factor receptor 4 ( FGFR4 ) inhibitor ( IC 50 =1.2 nM). FGFR4-IN-19 achieves high efficiency and isotype selectivity by covalently targeting a rare cysteine (C552) in the FGFR4 kinase domain. FGFR4-IN-19 can be used for hepatocellular carcinoma (HCC) research.
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