(Rac)-BDA-366

Overview

(Rac)-BDA-366 (example 2) is the despinner of BDA-366 ( HY-101083 ). BDA-366 is a potent Bcl-2 antagonist (Ki=3.3 nM), binding Bcl-2 -BH4 domain with high affinity and selectivity. BDA-366 induces conformational change in Bcl-2 that abrogates its antiapoptotic function, converting it from a survival molecule to a cell death inducer. BDA-366 suppresses growth of lung cancer cells.

Application

Products | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Bcl-2 Family

Product Information

• Catalog No.: HY-101083A
• CAS No.: 142645-19-0
• Molecular Formula: C24H29N3O4
• Molecular Weight: 423.50
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source