ZG-2291

Overview

ZG-2291 is a selective inhibitor targeting FIH (Factor Inhibiting HIF ) with oral activity. By binding to FIH , ZG-2291 promotes a conformational flip of a catalytically important tyrosine, enabling selective inhibition of FIH without affecting other 2OG oxygenases in the JmjC subfamily. ZG-2291k enhances thermogenesis in ob/ob mice and improves obesity-related symptoms and metabolic dysfunctions. ZG-2291 holds promise for research in the field of obesity-related diseases.

Application

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Product Information

• Catalog No.: HY-159120
• CAS No.: 2962103-40-6
• Molecular Formula: C17H12ClN3O5
• Molecular Weight: 373.75
• Purity: 98.08%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source