HDAC3-IN-4

Overview

HDAC3-IN-4 is a selective and orally active HDAC3 inhibitor with an IC 50 of 89 nM. HDAC3-IN-4 induces the degradation of PD-L1 by regulating cathepsin B (CTSB) in the lysosomes, with a DC 50 of 5.7 μM. HDAC3-IN-4 shows better selectivity for HDAC3 over HDAC1 , HDAC6 , HDAC7 , and HDAC8 .

Application

Products | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > HDAC

Product Information

• Catalog No.: HY-159172
• CAS No.: 2988762-46-3
• Molecular Formula: C22H25N5O2S
• Molecular Weight: 423.53
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source