TfR-1-IN-1 is a transferrin receptor-1 ( TfR-1 ) inhibitor with tumor cell-specific activity. TfR-1-IN-1 reduces TfR-1 expression, impairs mitochondrial function, induces cell apoptosis , necroptosis and ferroptosis , and increases intracellular iron (II) levels. TfR-1-IN-1 decreases the metabolic activity of cancer cells. TfR-1-IN-1 can be used for the research of ovarian cancer , breast cancer and acute myeloid leukemia.
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