NDI-101150

Overview

NDI-101150 is an orally active, potent and selective hematopoietic progenitor cell kinase 1 ( HPK1 ) inhibitor with an IC 50 of 0.7 nM. NDI-101150 blocks HPK1-mediated negative regulation of immune receptor signaling, inhibits immunosuppression of T cell activation, enhances antigen-specific antibody production and augments B-cell activation. NDI-101150 inhibits tumor growth in syngeneic tumor models, establishes durable antitumor immune memory, and synergizes with anti-PD1 to enhance exhausted T cell activity and drive tumor regressions. NDI-101150 can be used for the research of cancer , such as breast cancer and colon cancer .

Application

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Product Information

• Catalog No.: HY-159643
• CAS No.: 2628486-22-4
• Molecular Formula: C27H27FN6O2
• Molecular Weight: 486.54
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source