PD-1/PD-L1-IN-54

Overview

PD-1/PD-L1-IN-54 (Compound 6) is a moderately affinic PD-1/PD-L1 inhibitor (K D : PD-1 , 55.8 μM; PD-L1 , 46.4 μM; IC 50 : 88.6 μM). PD-1/PD-L1-IN-54 inhibits PD-1/PD-L1 interactions and shows anticancer activity by activating CD8 + T cells, upregulating PD-1 expression, and increasing secretion of IFN-γ and IL-2 . PD-1/PD-L1-IN-54 inhibits cancer cell proliferation and promotes apoptosis . PD-1/PD-L1-IN-54 also regulates T cell immunity through the PI3K/Akt pathway correlated with PD-1/PD-L1 .

Application

Products | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > PD-1/PD-L1 | Products > Signaling Pathways > IFNAR | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > PI3K | Products > Signaling Pathways > Akt

Product Information

• Catalog No.: HY-159892
• CAS No.: 1393644-68-2
• Molecular Formula: C17H17ClO7
• Molecular Weight: 368.77
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source