PXL770

Overview

PXL770 is an orally active, direct allosteric AMP-activated protein kinase ( AMPK ) activator. PXL770 decreases C26:0 levels, improves mitochondrial respiration, reduces expression of proinflammatory genes and induces expression of compensatory transporters ( ABCD2/3 ) in ALD fibroblasts/lymphocytes. PXL770 normalizes plasma VLCFA levels, significantly reduces elevated VLCFA levels in brain and spinal cord in Abcd1 KO mice. PXL770 improves glycemia, dyslipidemia, and insulin resistance in ob/ob and high-fat diet (HFD)-fed mice. PXL770 can be used for the study of X-linked adrenoleukodystrophy (ALD), autosomal dominant polycystic kidney disease and nonalcoholic steatohepatitis (NASH).

Application

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Product Information

• Catalog No.: HY-160004
• CAS No.: 1523493-53-9
• Molecular Formula: C23H18ClNO3S
• Molecular Weight: 423.91
• Purity: 99.56%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: ≥ 3 mg/mL (7.08 mM); Clear solution
• Availability: In-stock

Source

Original product source