GFH018 methylbenzenesulfonate

Overview

GFH018 is an orally active, selective and ATP-competitive TGF-βR1 inhibitor with an IC 50 of 40 nM. GFH018 reactivates the immune system by blocking the immunosuppression mediated by regulatory T cells and M2 macrophages. GFH018 inhibits tumor angiogenesis. GFH018 suppresses tumor growth in mouse tumor models. GFH018 can be used for the research of solid tumors, hepatocellular carcinoma, colorectal cancer , breast cancer , and relapsed/metastatic nasopharyngeal carcinoma.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > TGF-β Receptor | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-160215A
• CAS No.: 2345717-52-2
• Molecular Formula: C28H27N7O4S
• Molecular Weight: 557.62
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source