Balinatunfib

Overview

Balinatunfib (SAR-441566) is an orally active inhibitor of TNFR1 signaling. By binding to the central pocket of the soluble TNFα ( sTNFα ) trimer, Balinatunfib stabilizes an asymmetric conformation, blocking its binding to TNFR1 (without affecting TNFR2) and thus inhibiting downstream pathways. Balinatunfib has anti-inflammatory activity, and can be used in the study of autoimmune diseases.

Application

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Product Information

• Catalog No.: HY-160412
• CAS No.: 2248726-53-4
• Molecular Formula: C27H24F2N6O2
• Molecular Weight: 502.52
• Purity: 99.94%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (9.95 mM); Clear solution
• Availability: In-stock

Source

Original product source