O-Desmethyl dacomitinib

Overview

O-Desmethyl dacomitinib (PF-05199265) is the major circulating metabolite of dacomitinib ( HY-13272 ) and acts as a pan-epidermal growth factor receptor ( ErbB ) tyrosine kinase inhibitor. O-Desmethyl dacomitinib exhibits a much lower exposure level than dacomitinib in the body. O-Desmethyl dacomitinib is highly dependent on the enzymatic activity of CYP2D6 for its formation.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > JAK/STAT Signaling | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Drug Metabolite | Products > Signaling Pathways > EGFR

Product Information

• Catalog No.: HY-160828
• CAS No.: 2468202-15-3
• Molecular Formula: C23H23ClFN5O2
• Molecular Weight: 455.91
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source