RTx-161

Overview

RTx-161 is a DNA polymerase θ inhibitor with an IC 50 of 4.1 nM. RTx-161 induces DNA damage, PARP cleavage, apoptosis , and selectively kills homologous recombination-deficient (HRD) cells . RTx-161 acts synergistically with PARP inhibitors to suppress PARP inhibitor resistance in cancer cells . RTx-161 can be used for the research of BRCA G12C mutant cancer and HR -deficient cancers.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > DNA/RNA Synthesis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > PARP

Product Information

• Catalog No.: HY-161430
• CAS No.: 3035072-49-9
• Molecular Formula: C21H18F7N3O4
• Molecular Weight: 509.37
• Purity: 98.0%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Availability: In-stock

Source

Original product source