CDK5-IN-4 (compound 4) is a potent multikinase type-II inhibitor targeting CDK5 , with an IC 50 of 9.8 μM. CDK5-IN-4 also inhibits GSK-3α , GSK-3β , CDK9 , and CDK2 , with IC 50 values of 0.98, 4.00, 1.76, and 6.24 μM, respectively. CDK5-IN-4 can be used for glioblastoma research.
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