GQN-B37-E is a potent selective binder and inhibitor of MCL-1 . GQN-B37-E binds to the BH3-domain-binding pocket in MCL-1 . GQN-B37-E exhibits binding affinity for MCL-1 at the submicromolar range ( K i = 0.6 μM) without apparent binding to BCL-2 or BCL-XL .
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