SMARCA2-IN-7

Overview

SMARCA2-IN-7 (compound 12), a dual inhibitor of BRM and BRG1 ( IC 50 < 0.005 for both), has an anti-tumor proliferation effect that inhibits BRG1-deleted SKMEL5 tumor proliferation with a cell proliferation activity AAC 50 of 13 nM in SKMEL5. The cell proliferation activity AAC 50 of KRT880 in H1299 cells was 42 nM.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > SWI/SNF Complex

Product Information

• Catalog No.: HY-161886
• CAS No.: 2270879-43-9
• Molecular Formula: C11H9ClF2N4O2S
• Molecular Weight: 334.73
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source