METTL1-WDR4-IN-1

Overview

METTL1-WDR4-IN-1 (Compound 1) is a selective competitive inhibitor of the methyltransferase complex METTL1-WDR4 ( IC 50 = 144 μM). METTL1-WDR4-IN-1 inhibits the m 7 G methyltransferase activity of the METTL1-WDR4 complex, blocking m 7 G modification of PKM mRNA , reducing PKM2 protein expression, disrupting the METTL1/PKM2/H3K9la positive feedback loop, and simultaneously inhibiting PKM2 nuclear translocation-mediated CD155 transcriptional activation. METTL1-WDR4-IN-1 can inhibit tumor cell proliferation, weaken glycolytic metabolism, reverse tumor immune evasion (restoring NK cell and CD8 + T cell function), and regulate RNA epigenetic modification and the tumor immune microenvironment. METTL1-WDR4-IN-1 can be used in immunotherapy research for cancers such as colorectal cancer , and is particularly suitable for use in combination with PKM2 inhibitors to enhance anti-tumor treatment efficacy.

Application

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Product Information

• Catalog No.: HY-162080
• CAS No.: 374705-10-9
• Molecular Formula: C8H11N5O2S
• Molecular Weight: 241.27
• Purity: 99.61%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.75 mg/mL (11.40 mM); Clear solution
• Availability: In-stock

Source

Original product source