FAZ-3780

Overview

FAZ-3780 is an inhibitor that binds to the NTF2L domain of G3BP1/2 . FAZ-3780 binds to the NTF2L nsP3 of G3BP1 with high affinity, with a K d of 0.15 μM and a Pep-FRET IC 50 of 0.7 μM. FAZ-3780 targets the protein-protein interaction domain of G3BP1/2, and specifically inhibits the co-condensation of G3BP1, caprin 1 and RNA in vitro. FAZ-3780 inhibits stress granule formation and disassembles pre-formed stress granules. FAZ-3780 can be used in studies related to cancer and neurodegenerative diseases.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Neurodegenerative Disease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Neurological Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > DNA/RNA Synthesis

Product Information

• Catalog No.: HY-162289
• CAS No.: 3036029-78-1
• Molecular Formula: C35H50N4O5
• Molecular Weight: 606.80
• Purity: 99.68%
• Storage: -20°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Availability: In-stock

Source

Original product source