Topoisomerase I inhibitor 14 (Compound 4h) is an inhibitor for Topoisomerase I. Topoisomerase I inhibitor 14 inhibits proliferation of A549 and C6 with IC 50 s of 4.56 μM and 13.17 μM, without significant toxicity in healthy cells NIH3T3 ( IC 50 is 74.44 μM), which exhibits anticancer potency.
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