AZ'9567

Overview

AZ'9567 is an orally active MAT2a inhibitor with a pIC 50 of 9.1. AZ'9567 binds to MAT2a allosterically, reduces the synthesis of SAM , decreases SDMA levels, and exerts antiproliferative effects on MTAP -knockout cells. AZ'9567 depletes SAM , causes methionine accumulation in plasma and tissues, triggers adaptive disorders in one-carbon metabolism, transsulfuration metabolism and lipid metabolism, and induces oxidative stress, hepatic steatosis and lipid homeostasis imbalance. AZ'9567 can be used in studies related to MTAP-deficient/deleted cancers.

Application

Products | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy

Product Information

• Catalog No.: HY-162353
• CAS No.: 3056570-19-2
• Molecular Formula: C24H19F2N5O2
• Molecular Weight: 447.44
• Purity: 99.19%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source