USP1-IN-9

Overview

USP1-IN-9 (Compound 1m) is reversible and noncompetitive ubiquitin-specific proteases ( USP1 ) inhibitors with an IC 50 of 8.8 nM, which is designed and synthesized to pyrido[2,3-d]pyrimidin-7(8H)-one derivative based on the disclosed structure of ML323( HY-17543 ) and KSQ-4279 ( HY-145471 ). USP1-IN-9 displays excellent USP1/UAF inhibition and exhibits strong antiproliferation effect in breast cancer cells. USP1-IN-9 can generate enhanced cell killing with PARP inhibitor olaparib( HY-10162 ) in olaparib-resistant MDA-MB-436/OP cells, which is promising for research in the field of cancer .

Application

Products | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Deubiquitinase

Product Information

• Catalog No.: HY-162633
• CAS No.: 2925548-22-5
• Molecular Formula: C29H26F3N7O2
• Molecular Weight: 561.56
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source