LDR102

Overview

LDR102 (Compound 19h) is an inhibitor for receptor tyrosine kinase-like orphan receptor 1 ( ROR 1 ) with K i of 0.10 μM. LDR102 inhibits proliferation of cancer cells H1975, A549 and MDA-MB-231, with IC 50 of 0.36 μM, 1.37 μM and 0.47 μM. LDR102 exhibits antitumor efficacy in mice and good pharmacokinetic characteristics in rat models.

Application

Products | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Vitamin D Related/Nuclear Receptor | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > ROR

Product Information

• Catalog No.: HY-162640
• CAS No.: 3053223-31-4
• Molecular Formula: C33H27N5O3
• Molecular Weight: 541.60
• Purity: 99.78%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (4.62 mM); Clear solution
• Availability: In-stock

Source

Original product source