BRD-810

Overview

BRD-810 is a potent and selective MCL1 inhibitor with a K d of 0.3 nM. BRD-810 can specifically block the BH3 binding groove of MCL1, while having little effect on other anti-apoptotic proteins (such as Bcl-2 , Bcl-xL ). BRD-810 effectively destroys the MCL1-BAK complex ( IC 50 = 1.2 nM) in cancer cells, rapidly activates Caspase and induces cell apoptosis . BRD-810 can be used in the research of various cancers such as hematological tumors and solid tumors.

Application

Products | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-162858
• CAS No.: 2329719-65-3
• Molecular Formula: C39H44ClFN4O5
• Molecular Weight: 703.24
• Purity: 98.00%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source