diABZI-V/C-DBCO

Overview

diABZI-V/C-DBCO is a STING agonist with an EC 50 of 1.47 nM. diABZI-V/C-DBCO activates the STING pathway, induces the production of IFN-I , and stimulates the secretion of IFN-β . diABZI-V/C-DBCO serves as a substrate for cathepsin B , and releases active diABZI-amine via cathepsin B-mediated cleavage. In an orthotopic mouse model of breast cancer , diABZI-V/C-DBCO increases serum IFN-β levels and the frequency of granzyme B + CD8 + T cells. diABZI-V/C-DBCO is applicable to research related to triple-negative breast cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Triple-Negative Breast Cancer | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > STING | Products > Signaling Pathways > IFNAR

Product Information

• Catalog No.: HY-162874
• CAS No.: 3035557-60-6
• Molecular Formula: C78H89N19O13
• Molecular Weight: 1500.66
• Purity: 98.66%
• Storage: -20°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (1.67 mM); Clear solution
• Availability: In-stock

Source

Original product source