EGFR/c-Met-IN-1

Overview

EGFR/c-Met-IN-1 (compound TS-41) is a dual-target inhibitor of EGFR/c-Met . The IC 50 for inhibiting EGFR L858R and c-Met is 68.1 nM and 0.26 nM respectively. . EGFR/c-Met-IN-1 induces apoptosis and cell cycle arrest in A549-P cells, downregulating the phosphorylation of EGFR , c-Met, and downstream AKT . EGFR/c-Met-IN-1 inhibits tumor growth in vitro and in vivo.

Application

Products | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > EGFR | Products > Signaling Pathways > c-Met/HGFR

Product Information

• Catalog No.: HY-163006
• CAS No.: 3020728-68-8
• Molecular Formula: C30H25FN6O5
• Molecular Weight: 568.56
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source