SIRT4-IN-1

Overview

SIRT4-IN-1 is a selective and potent Sirtuin 4 ( Sirt4 ) inhibitor with an IC 50 of 16 μM for hSirt4. SIRT4-IN-1 also inhibits hSirt1, hSirt2, hSirt3, hSirt4 and hSirt6. SIRT4-IN-1 competes with acyl peptide substrate for Sirt4's acyl binding site, and is noncompetitive with NAD + . SIRT4-IN-1 increases glutamate dehydrogenase ( GDH ) activity and rescues pyruvate dehydrogenase ( PDH ) activity. SIRT4-IN-1 inhibits adipocyte differentiation and suppresses Sirt4 overexpression-induced increased differentiation. SIRT4-IN-1 can be used for the researches of cancer and metabolic disease .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Metabolic Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Sirtuin | Products > Signaling Pathways > Glutamate Dehydrogenase (GLDH) | Products > Signaling Pathways > PDHK

Product Information

• Catalog No.: HY-163316
• CAS No.: 3030697-87-8
• Molecular Formula: C19H13N5O6S3
• Molecular Weight: 503.53
• Purity: 99.94%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (4.96 mM); Clear solution
• Availability: In-stock

Source

Original product source