FGFR-IN-13

Overview

FGFR-IN-13 (compound III-30) is an irreversible covalent fibroblast growth factor receptor ( FGFR ) inhibitor. FGFR-IN-13 regulates endogenous FGFR1 ( IC 50 =0.20±0.02 nM) and FGFR4 ( IC 50 =0.40±0.03 nM) mediated signaling pathways by inhibiting the expression of key proteins. FGFR-IN-13 inhibits total-PARP and Bcl-2 protein expressions, and promote Cleaved-PARP and Bax protein expressions in a dose-dependent manner. FGFR-IN-13 has significant antitumor activity and oral activity.

Application

Products | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > FGFR

Product Information

• Catalog No.: HY-163527
• CAS No.: 2962941-25-7
• Molecular Formula: C23H21N5O3
• Molecular Weight: 415.44
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source