Anticancer agent 221 (Compound 4h) is an orally active anticancer agent and an antioxidant agent. Anticancer agent 221 exhibits cytotoxicity to cancer cells A549 ( IC 50 =22.09 µg/mL) and MCF-7 ( IC 50 =6.40 µg/mL), and induces apoptosis . Anticancer agent 221 exhibits antioxidant efficacy with an IC 50 of 42.46 μM in DPPH experiment. Anticancer agent 221 exhibits antitumor efficacy against breast cancer in mouse models.
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