Antitumor agent-171

Overview

Antitumor agent-171 (Compound 35) is an inhibitor for β-catenin/BCL9 interaction with IC 50 of 1.61 μM. Antitumor agent-171 exhibits high affinity to β-catenin with K d of 0.63 μM. Antitumor agent-171 inhibits the gene expression of axin2 with IC 50 of 0.84 μM. Antitumor agent-171 inhibits cell viability of HCT116 with IC 50 of 4.39 μM. Antitumor agent-171 activates T cells, promotes antigen presentation, and exhibits antitumor efficacy and good pharmacokinetic characteristics in mouse models.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > β-catenin

Product Information

• Catalog No.: HY-163767
• CAS No.: 3003004-76-7
• Molecular Formula: C35H45N7O5
• Molecular Weight: 643.78
• Purity: 98.48%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (7.77 mM); Clear solution
• Availability: In-stock

Source

Original product source