Antitumor agent-172

Overview

Antitumor agent-172 (Compound 28) is an inhibitor for β-catenin/BCL9 interaction with IC 50 of 3.92 μM. Antitumor agent-172 exhibits high affinity to β-catenin with K d of 82 nM. Antitumor agent-172 activates T cells, promotes antigen presentation, and exhibits antitumor efficacy and good pharmacokinetic characteristics in mouse models.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > β-catenin

Product Information

• Catalog No.: HY-163768
• CAS No.: 3027905-74-1
• Molecular Formula: C37H50N8O4
• Molecular Weight: 670.84
• Purity: 98.51%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (3.73 mM); Clear solution
• Availability: In-stock

Source

Original product source