Pacritinib citrate

Overview

Pacritinib (SB1518) citrate is a potent inhibitor of both wild-type JAK2 (IC 50 =23 nM) and JAK2 V617F mutant (IC 50 =19 nM). Pacritinib citrate also inhibits FLT3 (IC 50 =22 nM) and its mutant FLT3 D835Y (IC 50 =6 nM). Pacritinib citrate can be used for the research of acute myeloid leukemia (AML) and myelofibrosis (MF).

Application

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Product Information

• Catalog No.: HY-16379B
• CAS No.: 1228923-42-9
• Molecular Formula: C34H40N4O10
• Molecular Weight: 664.70
• Purity: 99.68%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 3 mg/mL (4.51 mM); Clear solution
• Availability: In-stock

Source

Original product source