GSK_WRN4

Overview

GSK_WRN4 is an orally active WRN helicase inhibitor ( pIC 50 =7.6). GSK_WRN4 induces DNA damage markers ( p21 , p-γH2AX , p-KAP1 ). GSK_WRN4 selectively inhibits microsatellite-unstable tumor growth in vitro and in vivo by inducing DNA double-strand breaks, particularly at expanded TA repeats and regions of DNA damage.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > DNA/RNA Synthesis

Product Information

• Catalog No.: HY-163942
• CAS No.: 2923008-66-4
• Molecular Formula: C16H20N2O4S
• Molecular Weight: 336.41
• Purity: 98.85%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (7.43 mM); Clear solution
• Availability: In-stock

Source

Original product source