PF-303

Overview

PF-303 is a potent, oral inhibitor of Bruton's tyrosine kinase ( BTK ) ( IC 50 =0.64 nM). The melamine portion of PF-303 forms a covalent bond with BTK's Cys481, which is reversible and exhibits a high selectivity compared to irreversible covalent BTK inhibitors. PF-303 can be used to model and study the effects of BTK inhibition on the mature immune system, including effects on B-cell subsets, antibody responses, and T-cell-mediated activation.

Application

Products | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Others | Products > Signaling Pathways > Btk

Product Information

• Catalog No.: HY-164002
• CAS No.: 1609465-78-2
• Molecular Formula: C22H21ClN6O2
• Molecular Weight: 436.89
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source