TNF-α-IN-18

Overview

TNF-α-IN-18 (Compound 61) is an inhibitor for TNF-α ( IC 50 of 1.8 μM), that inhibits TNF signaling pathway through block of NF-kB migration from cytoplasm to nucleus. TNF-α-IN-18 exhibits slight cytotoxicity to mouse fibroblast LM cell, with a CC 50 >50 μM. TNF-α-IN-18 ameliorates the TNF- or Lipopolysaccharide ( HY-D1056 )-induced sepsis in mouse models. TNF-α-IN-18 protects mice from rheumatoid arthritis.

Application

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Product Information

• Catalog No.: HY-164102
• CAS No.: 1272322-42-5
• Molecular Formula: C16H7ClF2O4
• Molecular Weight: 336.67
• Purity: 98.94%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source