17-Demethoxy-reblastatin

Overview

17-Demethoxy-reblastatin (17-DR) is an inhibitor for heat shock protein 90 ( Hsp90 ) , with an IC 50 of 1.82 μM for yeast Hsp90 ATPase. 17-Demethoxy-reblastatin inhibits the proliferation of cancer cell HepG2 and SMMC7721, reduces the colony formation, and induces apoptosis through mitochondria and caspase mediated pathway.

Application

Products | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > HSP | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-164372
• CAS No.: 299173-64-1
• Molecular Formula: C28H42N2O7
• Molecular Weight: 518.64
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source