SST0116CL1

Overview

SST0116CL1 is a HSP90 inhibitor ( IC 50 : 0.21 μM). SST0116CL1 binds to the ATP binding pocket of Hsp90 , and interferes with Hsp90 chaperone function thus resulting in client protein ( EGFR , CDK4 and AKT ) degradation. SST0116CL1 induces degradation of Her2 in BT-474 cell (IC 50 : 0.2 μM). SST0116CL1 has antiproliferative activity and inhibits tumor growth. SST0116CL1 can be used for the study of leukemia, gastric and ovarian carcinoma.

Application

Products | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Akt | Products > Signaling Pathways > HSP | Products > Signaling Pathways > EGFR | Products > Signaling Pathways > CDK

Product Information

• Catalog No.: HY-164399
• CAS No.: 1799802-29-1
• Molecular Formula: C22H31ClN4O6
• Molecular Weight: 482.96
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source