CLM3

Overview

CLM3, a pyrazolopyrimidine derivative, is a multiple tyrosine kinase inhibitor. CLM3 shows antiproliferative and proapoptotic activity on endothelial and cancer cells, synergistically enhanced by SN38 ( HY-13704 ). These effects are mainly due to its inhibition of phosphorylation of VEGFR-2 , EGFR and RET tyrosine kinases and their related signaling pathways.

Application

Products | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > VEGFR | Products > Signaling Pathways > EGFR | Products > Signaling Pathways > RET | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-164413
• CAS No.: 1312024-59-1
• Molecular Formula: C21H21N5
• Molecular Weight: 343.42
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source