A-1248767 is a MCL-1 inhibitor ( IC 50 =23.9 nM; K i =0.41 nM) with anticancer activity. A-1248767, a derivative of A-1210477 ( HY-12468 ), binds to MCL-1 with high affinity, induces the increase of intracellular MCL-1 protein, and promotes tumor cell apoptosis .
Products | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > Apoptosis
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