HG-6-63-01

Overview

HG-6-63-01 is a type II RET tyrosine kinase inhibitor ( TKI ). HG-6-63-01 also inhibits REarranged during Transfection ( RET ) kinase and signaling in human thyroid cancer cell lines carrying oncogenic RET alleles. HG-6-63-01 impairs phosphorylation and signalling of RET oncogenic mutants. HG-6-63-01 blunts proliferation of RET/C634R and RET/M918T-transformed fibroblasts and of RET mutant thyroid cancer cells, which is promising for research of cancers harboring oncogenic activation of RET .

Application

Products | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > RET

Product Information

• Catalog No.: HY-164482
• CAS No.: 2177298-99-4
• Molecular Formula: C31H31ClF3N5O
• Molecular Weight: 582.06
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source