LSN3074753

Overview

LSN3074753, an analog of LY3009120 ( HY-12558 ), is a pan- RAF and Raf dimer inhibitor. LSN3074753 demonstrates activity against tumor cells with MAPK pathway activation driven by BRAF monomer or RAF dimers including BRAF- or KRAS-mutant colorectal cancer . LSN3074753 combined with Cetuximab ( HY-P9905 ) shows additive and synergistic effects for colorectal cancer PDX models, particularly those with KRAS or BRAF mutation.

Application

Products | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Raf

Product Information

• Catalog No.: HY-164492
• CAS No.: 1455031-68-1
• Molecular Formula: C24H30FN5O2
• Molecular Weight: 439.53
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source