KL-50

Overview

KL-50 is a selective toxin toward tumors that lack the DNA repair protein O 6 -methylguanine-DNA-methyltransferase ( MGMT ), which reverses the formation of O 6 -alkylguanine lesions. KL-50 activates DNA damage response pathways and cycle arrest in MGMT-cells, independent of mismatch repair (MMR). KL-50 is promising for research of brain tumors that lack the DNA repair protein MGMT .

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > DNA/RNA Synthesis

Product Information

• Catalog No.: HY-164496
• CAS No.: 1161826-19-2
• Molecular Formula: C7H7FN6O2
• Molecular Weight: 226.17
• Purity: 99.82%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source