PF-7006

Overview

PF-7006 is an Mps1 kinase inhibitor with a K i value of 0.27 nM and an IC 50 value of 2.5 nM. PF-7006 interferes with cell cycle checkpoints by inhibiting the catalytic activity of Mps1 , reducing histone H3 levels, and shortening the duration of mitosis , leading to apoptosis in cancer cells. Combined use of PF-7006 with Palbociclib ( HY-50767 ) increases cancer cell tolerance to PF-7006. PF-7006 can be used for breast cancer research.

Application

Products | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Cytoskeleton | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Mitosis | Products > Signaling Pathways > Mps1

Product Information

• Catalog No.: HY-164519
• CAS No.: 2771955-09-8
• Molecular Formula: C22H26N8O2
• Molecular Weight: 434.49
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source