TQ05310

Overview

TQ05310 is an orally available inhibitor of IDH2 mutants, targeting both IDH2-R140Q ( IC 50 =136.9 nM) and IDH2-R172K ( IC 50 =37.9 nM) mutants. TQ05310 inhibits the production of 2-hydroxyglutarate (2-HG) and induces differentiation of cells expressing IDH2-R140Q and IDH2-R172K by inhibiting the enzymatic activity of mutant IDH2 . TQ05310 can be used for the study of acute myeloid leukemia.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Isocitrate Dehydrogenase (IDH)

Product Information

• Catalog No.: HY-164542
• CAS No.: 2071196-10-4
• Molecular Formula: C19H17F6N7O
• Molecular Weight: 473.37
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source