pan-KRAS-IN-16 (Compound 3344) is an anti- RAS small molecule derived from an intracellular antibody fragment with pan-RAS-effector protein-protein interaction inhibitor properties. pan-KRAS-IN-16 binds to a hydrophobic pocket near to the effector-binding switch regions of RAS . pan-KRAS-IN-16 prevents endogenous RAS -dependent signaling in tumor cell lines.
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