Spliceostatin A

Overview

Spliceostatin A, the FR901464 ( HY-16212 ) methylated derivative, is a potent anti-tumor agent. Spliceostatin A inhibits splicing and promotes pre-mRNA accumulation by binding SF3B1 . SF3B1 is a subcomplex of U2 small nuclear ribonucleoprotein in the spliceosome. Spliceostatin A induces Apoptosis in chronic lymphocytic leukemia (CLL) cells.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > SF3B1

Product Information

• Catalog No.: HY-16466
• CAS No.: 391611-36-2
• Molecular Formula: C28H43NO8
• Molecular Weight: 521.64
• Purity: 96.64%
• Storage: -80°C, protect from light
• Availability: In-stock

Source

Original product source