Acetyl zingerone

Overview

Acetyl zingerone is an analog of Zingerone ( HY-14621 ). Acetyl zingerone downregulates the expression of ROS metabolism-related genes, fibroblast senescence-related genes, keratinocyte differentiation-related genes, and IL-17A target genes. Acetyl zingerone inhibits the activities of MMP-1 , MMP-3 , and MMP-12 , as well as the activation of NLRP3 inflammasome, pyroptosis ( pyroptosis ), ferroptosis ( ferroptosis ), cartilage destruction, and UVA-induced cyclobutane pyrimidine dimer formation. Acetyl zingerone upregulates the expression of collagen , proteoglycan, extracellular matrix glycoprotein , Notch pathway, and GPX4 gene, activates Nrf2 and HO-1 , induces extracellular matrix synthesis and PINK1 / Parkin -mediated mitophagy ( mitophagy ), and promotes chondrocyte survival. Acetyl zingerone alleviates the progression of osteoarthritis in mice . Acetyl zingerone can be used in research related to skin aging, inflammatory skin diseases, osteoarthritis, melanoma, and non-melanoma skin cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Arthritis | Products > Disease Areas > Melanoma | Products > Disease Areas > Osteoarthritis | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Autophagy | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > MMP | Products > Signaling Pathways > Pyroptosis | Products > Signaling Pathways > Ferroptosis | Products > Signaling Pathways > Notch | Products > Signaling Pathways > Keap1-Nrf2 | Products > Signaling Pathways > PINK1/Parkin | Products > Signaling Pathways > Mitophagy | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-164826
• CAS No.: 30881-23-3
• Molecular Formula: C13H16O4
• Molecular Weight: 236.26
• Purity: 99.34%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (21.16 mM); Clear solution
• Availability: In-stock

Source

Original product source