TTK/PLK1-IN-1 (Formula I) is the inhibitor for threonine tyrosine kinase ( TTK ) and polo-like kinase 1 ( PLK1 ) with IC 50 of 7 nM and 72 nM. TTK/PLK1-IN-1 regulates spindle assembly checkpoint (SAC), and exhibits antitumor efficacy against TNBC.
Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Cytoskeleton | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Mps1 | Products > Signaling Pathways > Polo-like Kinase (PLK)
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