Riviciclib (P276-00 free base) is a potent cyclin-dependent kinase ( CDK ) inhibitor, which inhibits CDK9-cyclinT1 , CDK4-cyclin D1 , and CDK1-cyclinB with IC 50 s of 20 nM, 63 nM, and 79 nM, respectively. Riviciclib shows antitumor activity on cisplatin-resistant cells.
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