JAK1-IN-17

Overview

JAK1-IN-17 (Compound 31) is a highly selective inhibitor of JAK1 with a K i of 1.9 nM. JAK1-IN-17 exhibits a low whole blood shift, which allows maintaining good whole blood potency. JAK1-IN-17 is also a nitrile-containing analogue with consistent, yet weak reversible inhibition of CYP3A4 using a midazolam probe ( IC 50 = 7.9 μM). JAK1-IN-17 can be studied in cancer research.

Application

Products | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > JAK/STAT Signaling | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Signaling Pathways > JAK

Product Information

• Catalog No.: HY-16641
• CAS No.: 1315490-71-1
• Molecular Formula: C17H19N5O
• Molecular Weight: 309.37
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source